Pre-Conference Workshop: ADAPT3 penicillin allergy de-labelling for non-allergists in clinical practice
Thursday 13 August 2026 - Limited to 50 attendees per workshop
EARN 5 CLINICAL CPD POINTS
Workshop Aim: To equip non-allergist healthcare workers at Cape Town hospitals with the knowledge, skills, and confidence to practise high-quality antimicrobial stewardship — including safely identifying and de-labelling low-risk penicillin allergy patients, understanding the evolving landscape of antimicrobial resistance in South Africa, and applying sound principles for the appropriate use of advanced antibiotics against resistant organisms such as carbapenem-resistant Enterobacterales (CRE) and metallo-β-lactamase (MBL) producers. Participants will leave with a practical framework for risk-stratifying penicillin allergy labels using the PEN-FAST tool and the EAACI tiered classification, will be competent to perform direct oral challenges in appropriate clinical settings, and will understand how de-labelling and prudent prescribing together preserve our antibiotic armamentarium. This CPD-accredited workshop impact will be measured at 6 months via the iNAAN app to quantify post-training de-labelling activity.
Learning Objectives: By the end of this workshop, participants will be able to:
- Articulate the patient-level and public health case for penicillin allergy de-labelling, including the impact on AMR
- Interpret the iNAAN safety dataset and apply its findings to clinical decision-making
- Use the PEN-FAST clinical decision rule to screen and risk-stratify patients with penicillin allergy labels
- Classify patients into Tiers 1–3 using the EAACI consensus risk-stratification framework
- Plan and safely conduct a direct oral challenge (DOC) for low-risk patients in their clinical setting
- Recognise and manage adverse reactions to DOC, including mild reactions and anaphylaxis
- Register on the iNAAN app and commit to capturing de-labelling outcomes for a 6-month follow-up
- Describe the evolving epidemiology of antimicrobial resistance in South Africa, including the rise of carbapenem-resistant Enterobacterales (CRE) and metallo-β-lactamase (MBL)–producing organisms
- Apply an evidence-based, stewardship-aligned approach to prescribing advanced antibiotics for CRE and MBL infections
| TIME | THURSDAY 13 AUGUST 2026 – TOPICS | SPEAKER | DURATION |
|---|---|---|---|
| 07:30 | Registration and Tea and Coffee | ||
| 08:00 | Welcome, Introduction and Pre-Workshop Survey
| Prof Peter | 20 min |
| 08:20 | Evolving Resistance Patterns in South Africa: The Rise of CRE and MBL
| Prof Dlamini | 30 min |
| 08:50 | The Case for De-labelling: Patient Harm and AMR
| Dr Day | 20 min |
| 09:10 | The Overwhelming Safety Data: The iNAAN Dataset
| Prof Peter | 30 min |
| 09:40 | Tea and Coffee break | ||
| 10:00 | Cape Town Data: Penicillin Allergy Prevalence and Our iNAAN Experience
| Dr McDougall | 20 min |
| 10:20 | When Someone Reacts: What Does It Look Like?
| Dr McDougall | 20 min |
| 10:40 | The Hong Kong Experience: Nurse-Led De-labelling at Scale
| Prof Li | 30 min |
| 11:10 | Comfort Break | ||
| 11:20 | Risk Assessment: Tier 1 and Tier 2 Patients
| Dr Deetlefs / Dr McDougall | 30 min |
| 11:50 | Using PEN-FAST to Screen Tier 3 Patients
| Dr Deetlefs / Dr McDougall | 30 min |
| 12:20 | Light lunch | ||
| 13:20 | The Direct Oral Challenge: Where, How, and When to Observe
| Dr Deetlefs / Dr McDougall | 40 min |
| 14:00 | Staged Implementation: From Your Ward to Routine Practice
| Prof Peter | 20 min |
| 14:20 | Appropriate Prescribing for Advanced Resistance: Treating CRE and MBL Infections
| Prof Dlamini | 30 min |
| 14:50 | Getting Started: The iNAAN App and Your 6-Month Commitment
| Dr Deetlefs / Dr McDougall | 20 min |
| 15:10 | Post-Workshop Survey and Closing
| Prof Peter | 20 min |
| 15:30 | Workshop Ends | ||
Disclaimer: The organisers reserve the right to make changes to the conference programme, including speakers, session topics, presentation times, and venues, should circumstances require. Every effort will be made to keep delegates informed of any updates. While all reasonable care has been taken in compiling the programme, the organisers accept no responsibility for any errors, omissions, or changes that may occur.
Please note: You will be able to move freely between the different pre-conference workshop sessions.





